Repligen is a premier American bioprocessing company headquartered in Waltham, Massachusetts. Since its founding in 1981 by MIT professors, the company has spent over four decades fulfilling its mission to "Inspire Advances in Bioprocessing," becoming a global leader in the development of technologies for biological drug manufacturing. Repligen is internationally renowned for its expertise in filtration, chromatography, and process analytics, specifically through its iconic Spectra/Por® dialysis membranes and XCell® ATF systems. By focusing on intensifying biopharmaceutical production workflows—integrating single-use technologies and advanced fluid management—the brand ensures that researchers and manufacturers can maximize yield and purity. Today, Repligen is an essential partner for life sciences and biopharmaceutical firms in over 100 countries, delivering high-tech engineering that accelerates the production of monoclonal antibodies, vaccines, and gene therapies worldwide.
The Repligen range at LabFriend features professional life science solutions, headlined by their world-standard Spectra/Por® dialysis membranes and Float-A-Lyzer® G2 ready-to-use devices. These are essential for the efficient separation, desaltation, and purification of proteins and nucleic acids. For specialized concentration and buffer exchange, the brand provides advanced purification support through their range of tangential flow filtration (TFF) cassettes and hollow fiber filters, designed for scalable performance from lab to production. Their portfolio also encompasses essential analytical measurement aids, featuring specialized Slope Spectroscopy® tools and pre-packed OPUS® chromatography columns for rapid process development. To support modern genomic and proteomic workflows, Repligen offers high-purity Biotech-grade membranes that are certified free of heavy metals and sulfides. By choosing Repligen through LabFriend, you benefit from competitive pricing and fast shipping on premium bioprocessing technology designed for professional consistency and breakthrough efficiency.
Why Choose Repligen for Your Laboratory?
- Pioneer in Upstream Intensification: Repligen is the innovator behind the XCell® ATF technology, which significantly increases cell density and productivity in bioreactor processes.
- Broadest Range of Dialysis Membranes: With the Spectra/Por® portfolio, Repligen offers the widest selection of Molecular Weight Cut-Offs (MWCO) and chemistries to suit any molecular separation need.
- Unmatched Purity for Sensitive Samples: Their Biotech-grade Cellulose Ester (CE) membranes offer the lowest protein binding and highest purity for critical research in proteomics and drug discovery.
- Scalable Solutions: Repligen technologies are designed to bridge the gap between benchtop research and commercial-scale manufacturing, ensuring a seamless tech transfer.
- Innovative "Ready-to-Use" Formats: From pre-wetted dialysis tubing to pre-packed chromatography columns, Repligen products are engineered to save time and reduce the risk of human error.
Frequently Asked Questions
1. How do I choose the correct Molecular Weight Cut-Off (MWCO) for dialysis?
To maximize the dialysis rate while ensuring high sample recovery, select an MWCO that is approximately half the molecular weight of the macromolecule you wish to retain.
2. What is the difference between RC and CE dialysis membranes?
Regenerated Cellulose (RC) is robust and has good chemical compatibility for general use, while Cellulose Ester (CE) is ultra-pure with significantly lower protein binding, ideal for sensitive biological samples.
3. Are Spectra/Por® membranes ready to use out of the box?
Standard RC membranes may require a brief soak in deionized water to remove preservatives (glycerin). Biotech-grade membranes are typically ready-to-use after a quick rinse to remove trace sodium azide.
4. Can I use Repligen TFF cassettes in systems from other manufacturers?
Yes, many Repligen TangenX® SIUS® cassettes are designed to be compatible with industry-standard holders, allowing for easy integration into your existing filtration setup.
